Association of Habitual Daily Physical Activity With Glucose Tolerance and ß-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study.
Diabetes Care
; 42(8): 1521-1529, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31177181
ABSTRACT
OBJECTIVE:
We examined the relationship between habitual daily physical activity and measures of glucose tolerance, insulin sensitivity, and ß-cell responses in adults with impaired glucose tolerance (IGT) or drug-naive, recently diagnosed type 2 diabetes. RESEARCH DESIGN ANDMETHODS:
Participants included 230 adults (mean ± SD age 54.5 ± 8.5 years, BMI 35 ± 5.5 kg/m2; 42.6% women) who underwent a 3-h oral glucose tolerance test (OGTT) and hyperglycemic clamp. Wrist accelerometers worn for 7 consecutive days measured total physical activity counts (TAC) (daily mean 233,460 [â¼50th percentile for age]). We evaluated whether TAC was associated with fasting plasma glucose, OGTT 2-h plasma glucose or glucose incremental area under the curve (G-iAUC), hyperglycemic clamp measures of insulin sensitivity (steady-state glucose infusion rate/insulin [M/I]) and ß-cell responses (acute C-peptide response to glucose, steady-state C-peptide, and maximal ß-cell response), and OGTT C-peptide index (ΔC-peptide0-30/Δglucose0-30).RESULTS:
After adjustments for confounders, there was no association of TAC with fasting plasma glucose, 2-h glucose, or G-iAUC. Higher TAC was associated with higher insulin sensitivity (M/I). After adjusting for M/I, higher TAC was not associated with measures of ß-cell response.CONCLUSIONS:
In adults with IGT or drug-naive, recently diagnosed type 2 diabetes, higher levels of habitual physical activity are associated with higher insulin sensitivity. Further studies are needed to understand why higher levels of physical activity are not associated with better ß-cell response.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucemia
/
Ejercicio Físico
/
Intolerancia a la Glucosa
/
Diabetes Mellitus Tipo 2
/
Células Secretoras de Insulina
/
Terapia por Ejercicio
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diabetes Care
Año:
2019
Tipo del documento:
Article
País de afiliación:
Israel