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A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.
Khoury, Samar; Piltonen, Marjo H; Ton, Anh-Tien; Cole, Tiffany; Samoshkin, Alexander; Smith, Shad B; Belfer, Inna; Slade, Gary D; Fillingim, Roger B; Greenspan, Joel D; Ohrbach, Richard; Maixner, William; Neely, G Gregory; Serohijos, Adrian W R; Diatchenko, Luda.
Afiliación
  • Khoury S; Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.
  • Piltonen MH; Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.
  • Ton AT; Department of Biochemistry, Robert Cedergren Centre on Bioinformatics and Genomics, University of Montreal, Montreal, Quebec, Canada.
  • Cole T; Dr John and Anne Chong Laboratory for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
  • Samoshkin A; Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.
  • Smith SB; School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Belfer I; Department of Anesthesia, Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC.
  • Slade GD; National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD.
  • Fillingim RB; Department of Dental Ecology, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC.
  • Greenspan JD; University of Florida Pain Research and Intervention Center of Excellence, College of Dentistry, University of Florida, Gainesville, FL.
  • Ohrbach R; Department of Neural and Pain Sciences, Brotman Facial Pain Clinic, School of Dentistry, University of Maryland, Baltimore, MD.
  • Maixner W; Department of Oral Diagnostic Services, University at Buffalo, Buffalo, NY.
  • Neely GG; Department of Anesthesia, Center for Translational Pain Medicine, Duke University Medical Center, Durham, NC.
  • Serohijos AWR; Dr John and Anne Chong Laboratory for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.
  • Diatchenko L; Department of Biochemistry, Robert Cedergren Centre on Bioinformatics and Genomics, University of Montreal, Montreal, Quebec, Canada.
Ann Neurol ; 86(2): 168-180, 2019 08.
Article en En | MEDLINE | ID: mdl-31177555
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descarboxilasas de Aminoácido-L-Aromático / Dolor Facial / Serotonina / Sustitución de Aminoácidos / Estudios de Asociación Genética / Síntomas sin Explicación Médica Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descarboxilasas de Aminoácido-L-Aromático / Dolor Facial / Serotonina / Sustitución de Aminoácidos / Estudios de Asociación Genética / Síntomas sin Explicación Médica Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos