Colletopeptides A-D, Anti-inflammatory Cyclic Tridepsipeptides from the Plant Endophytic Fungus Colletotrichum sp. S8.
J Nat Prod
; 82(6): 1434-1441, 2019 06 28.
Article
en En
| MEDLINE
| ID: mdl-31181925
ABSTRACT
Four new hybrid peptide-polyketide cyclic tridepsipeptides, colletopeptides A-D (1-4), were isolated and characterized from the endophytic fungus Colletotrichum sp. S8 derived from the stems of Rubia podantha with the guidance of LC-UV-MS detection. Their structures were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-4 are rare natural 12-membered cyclic tridepsipeptides containing a 3,5,11-trihydroxy-2-methyl dodecanoic acid unit in their structures. 1-4 inhibited lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages with the IC50 values of 8.3, 38.7, 13.5, and 22.2 µM, respectively. 1 also inhibited the production of inflammatory factors IL-6 and TNF-α, and decreased the phosphorylation of NF-κB-associated proteins IκBα and p65.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
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FN-kappa B
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Factor de Necrosis Tumoral alfa
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Colletotrichum
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Depsipéptidos
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Inhibidor NF-kappaB alfa
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Macrófagos
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Antiinflamatorios
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Óxido Nítrico
Idioma:
En
Revista:
J Nat Prod
Año:
2019
Tipo del documento:
Article