SCANVIS: a tool for SCoring, ANnotating and VISualizing splice junctions.
Bioinformatics
; 35(22): 4843-4845, 2019 11 01.
Article
en En
| MEDLINE
| ID: mdl-31197308
ABSTRACT
MOTIVATION The association of splicing signatures with disease is a leading area of study for prognosis, diagnosis and therapy. We present a novel fast-performing annotation-dependent tool called SCANVIS for scoring and annotating splice junctions (SJs), with an efficient visualization tool that highlights SJ details such as frame-shifts and annotation support for individual samples or a sample cohort. RESULTS:
Using publicly available samples, we show that the tissue specificity inherent in splicing signatures is maintained with the Relative Read Support scoring method in SCANVIS, and we showcase some visualizations to demonstrate the usefulness of incorporating annotation details into sashimi plots. AVAILABILITY AND IMPLEMENTATION https//github.com/nygenome/SCANVIS and https//bioconductor.org/packages/SCANVIS. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Empalme del ARN
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos