IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility.
Andrologia
; 51(8): e13340, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31197867
Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME criteria and then injected. The zygotes were cultured in time-lapse monitoring system (TLM) for 3 days. A total of 650 embryos were developed and assessed using TLM in two groups. Data showed the rate of fragmentation had significant correlation with different aetiologies (p = 0.01), and the timing of s1, t4, s2 and t5 occurred significantly later in oligoasthenoteratozoospermia (OAT) patients compared with others (p < 0.05). In IMSI group, there were no differences in the TLM parameters among different aetiologies (p > 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inyecciones de Esperma Intracitoplasmáticas
/
Desarrollo Embrionario
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Embrión de Mamíferos
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Infertilidad Masculina
Tipo de estudio:
Clinical_trials
Límite:
Adult
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Female
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Humans
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Male
/
Pregnancy
Idioma:
En
Revista:
Andrologia
Año:
2019
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Alemania