Your browser doesn't support javascript.
loading
Structure of the Helicobacter pylori Cag type IV secretion system.
Chung, Jeong Min; Sheedlo, Michael J; Campbell, Anne M; Sawhney, Neha; Frick-Cheng, Arwen E; Lacy, Dana Borden; Cover, Timothy L; Ohi, Melanie D.
Afiliación
  • Chung JM; Life Sciences Institute, University of Michigan, Ann Arbor, United States.
  • Sheedlo MJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, United States.
  • Campbell AM; Department of Medicine, Vanderbilt University School of Medicine, Nashville, United States.
  • Sawhney N; Department of Medicine, Vanderbilt University School of Medicine, Nashville, United States.
  • Frick-Cheng AE; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, United States.
  • Lacy DB; Department of Immunology and Microbiology, University of Michigan School of Medicine, Ann Arbor, United States.
  • Cover TL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, United States.
  • Ohi MD; Veterans Affairs Tennessee Valley Healthcare System, Nashville, United States.
Elife ; 82019 06 18.
Article en En | MEDLINE | ID: mdl-31210639
Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS assembly, which we describe as three sub-assemblies: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and central stalk. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system assemblies ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Sistemas de Secreción Tipo IV Idioma: En Revista: Elife Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Sistemas de Secreción Tipo IV Idioma: En Revista: Elife Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido