Immunoglobulin gene rearrangement in immunoproliferative small intestinal disease (IPSID).
J Clin Pathol
; 40(11): 1291-7, 1987 Nov.
Article
en En
| MEDLINE
| ID: mdl-3121678
ABSTRACT
Analysis of DNA from the mucosal tissue of three patients with immunoproliferative small intestinal disease (IPSID) and alpha chain disease, two of whom had early stage disease responsive to antibiotics, showed monoclonal heavy and light chain gene rearrangements in all cases. These findings suggest that IPSID is neoplastic even in its early stages, but that the neoplastic cells respond to normal stimuli. Monoclonal lymphoid populations could not be detected in circulating lymphocytes from these patients, which raises the possibility that the circulatory pathways of lymphocytes derived from human gut associated lymphoid tissue may not necessarily parallel those in experimental animals.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad Inmunoproliferativa del Intestino Delgado
/
Genes de Inmunoglobulinas
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pathol
Año:
1987
Tipo del documento:
Article