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Computer Design of Low-Molecular-Weight Inhibitors of Coagulation Factors.
Kabankin, A S; Sinauridze, E I; Lipets, E N; Ataullakhanov, F I.
Afiliación
  • Kabankin AS; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, 119991, Russia. rla2001@mail.ru.
  • Sinauridze EI; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, 119991, Russia.
  • Lipets EN; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117997, Russia.
  • Ataullakhanov FI; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, 119991, Russia.
Biochemistry (Mosc) ; 84(2): 119-136, 2019 Feb.
Article en En | MEDLINE | ID: mdl-31216971
ABSTRACT
The review discusses main approaches to searching for new low-molecular-weight inhibitors of coagulation factors IIa, Xa, IXa, and XIa and the results of such studies conducted from 2015 to 2018. For each of these factors, several inhibitors with IC50 < 10 nM have been found, some of which are now tested in clinical trials. However, none of the identified inhibitors meets the requirements for an "ideal" anticoagulant, so further studies are required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Coagulación Sanguínea / Diseño Asistido por Computadora / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochemistry (Mosc) Año: 2019 Tipo del documento: Article País de afiliación: Rusia
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Coagulación Sanguínea / Diseño Asistido por Computadora / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochemistry (Mosc) Año: 2019 Tipo del documento: Article País de afiliación: Rusia