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Anti-inflammatory effect of the medicinal herbal mixture infusion, Horchata, from southern Ecuador against LPS-induced cytotoxic damage in RAW 264.7 macrophages.
Guevara, Mabel; Tejera, Eduardo; Iturralde, Gabriel A; Jaramillo-Vivanco, Tatiana; Granda-Albuja, María G; Granja-Albuja, Silvana; Santos-Buelga, Celestino; González-Paramás, Ana M; Álvarez-Suarez, José M.
Afiliación
  • Guevara M; Grupo de Investigación en Biotecnología Aplicada a Biomedicina (BIOMED), Universidad de Las Américas, Quito, Ecuador.
  • Tejera E; Facultad de Ingeniería y Ciencias Aplicadas (FICA), Grupo de Bio-Quimioinformática (CBQ), Universidad de Las Américas, Quito, Ecuador.
  • Iturralde GA; Facultad de Ingeniería y Ciencias Aplicadas (FICA), Universidad de Las Américas, Quito, Ecuador.
  • Jaramillo-Vivanco T; Jardín Botánico de Quito, Quito, Ecuador.
  • Granda-Albuja MG; Laboratorios de Investigación, Universidad de Las Américas, Quito, Ecuador.
  • Granja-Albuja S; Departamento de Biotecnología. Escuela Politécnica del Ejército, Quito, Ecuador.
  • Santos-Buelga C; Grupo de Investigación en Polifenoles, Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain.
  • González-Paramás AM; Grupo de Investigación en Polifenoles, Universidad de Salamanca, Campus Miguel de Unamuno, 37007, Salamanca, Spain. Electronic address: paramas@usal.es.
  • Álvarez-Suarez JM; Facultad de Ingeniería y Ciencias Aplicadas (FICA), Grupo de Investigación en Biotecnología Aplicada a Biomedicina (BIOMED), Universidad de Las Américas, Quito, Ecuador. Electronic address: jose.alvarez@udla.edu.ec.
Food Chem Toxicol ; 131: 110594, 2019 Sep.
Article en En | MEDLINE | ID: mdl-31226431
The phytochemical composition and the antioxidant and anti-inflammatory activities of a mixture of 23 plants, named Horchata, traditionally consumed in Ecuador, have been evaluated. The study was carried out using the hydroalcoholic extract (HHext) and infusion (IHext) of the horchata plant mixture. It was verified that thermal treatment affected the contents of vitamin C and carotenoids, but hardly those of polyphenols, which would be the main bioactive compounds in the infusion, the common form of preparation of horchata for consumption. Among phenolic compounds, caffeoylquinic acids, flavones and flavonols (mostly quercetin glycosides) were prominent. Both HHext and IHext extracts managed to protect RAW 264.7 macrophages against LPS-induced cytotoxic damage, increasing the levels of endogenous antioxidant enzymes and modulating the production of pro-inflammatory and anti-inflammatory cytokines. Greater protective effects were obtained for HHext compared to IHext, which was in agreement with its higher content of phenolic compounds favoured by a more efficient extraction in the hydroalcoholic medium. Nonetheless, the infusion still maintained a significant antioxidant and anti-inflammatory activity, which would support the protective effects on health traditionally attributed to its consumption by the population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Antiinflamatorios / Antioxidantes Límite: Animals País/Región como asunto: America do sul / Ecuador Idioma: En Revista: Food Chem Toxicol Año: 2019 Tipo del documento: Article País de afiliación: Ecuador Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Antiinflamatorios / Antioxidantes Límite: Animals País/Región como asunto: America do sul / Ecuador Idioma: En Revista: Food Chem Toxicol Año: 2019 Tipo del documento: Article País de afiliación: Ecuador Pais de publicación: Reino Unido