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A Novel, High-sensitivity, Bacteriophage-based Assay Identifies Low-level Mycobacterium tuberculosis Bacteremia in Immunocompetent Patients With Active and Incipient Tuberculosis.
Verma, Raman; Swift, Benjamin M C; Handley-Hartill, Wade; Lee, Joanne K; Woltmann, Gerrit; Rees, Catherine E D; Haldar, Pranabashis.
Afiliación
  • Verma R; Department of Respiratory Sciences, National Institute for Health Research Respiratory Biomedical Research Centre, University of Leicester, Herts.
  • Swift BMC; Royal Veterinary College, Hawkshead Campus, Herts.
  • Handley-Hartill W; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Leicestershire.
  • Lee JK; Department of Respiratory Sciences, National Institute for Health Research Respiratory Biomedical Research Centre, University of Leicester, Herts.
  • Woltmann G; Department of Respiratory Medicine, University Hospitals of Leicester National Health Service Trust, Glenfield Hospital, United Kingdom.
  • Rees CED; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Leicestershire.
  • Haldar P; Department of Respiratory Sciences, National Institute for Health Research Respiratory Biomedical Research Centre, University of Leicester, Herts.
Clin Infect Dis ; 70(5): 933-936, 2020 02 14.
Article en En | MEDLINE | ID: mdl-31233122
ABSTRACT
The haematogenous dissemination of Mycobacterium tuberculosis (Mtb) is critical to the pathogenesis of progressive tuberculous infections in animal models. Using a novel, phage-based blood assay, we report the first concordant evidence in well-characterized, immunocompetent human cohorts, demonstrating associations of Mtb bacteremia with progressive phenotypes of latent infection and active pulmonary tuberculosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriófagos / Tuberculosis / Tuberculosis Pulmonar / Bacteriemia / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacteriófagos / Tuberculosis / Tuberculosis Pulmonar / Bacteriemia / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2020 Tipo del documento: Article