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Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites.
Yu, Zaikuan J; Roesner, Joseph M; Lutz, Ryan; Liang, Yuexia; Baker, James; Smith, Dustin M; Fan, Peter W.
Afiliación
  • Yu ZJ; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, 47907, United States.
  • Roesner JM; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA, 02115, United States.
  • Lutz R; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, United States.
  • Liang Y; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, 19486, United States.
  • Baker J; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA, 02115, United States.
  • Smith DM; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA, 02115, United States.
  • Fan PW; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA, 02115, United States. Electronic address: peter.weijen.fan@merck.com.
Drug Metab Pharmacokinet ; 34(5): 308-316, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31235362
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperacilina / Ácidos Carboxílicos / Indometacina / Carboxilesterasa / Clopidogrel Límite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperacilina / Ácidos Carboxílicos / Indometacina / Carboxilesterasa / Clopidogrel Límite: Humans Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido