Your browser doesn't support javascript.
loading
Chondroitinase improves anatomical and functional outcomes after primate spinal cord injury.
Rosenzweig, Ephron S; Salegio, Ernesto A; Liang, Justine J; Weber, Janet L; Weinholtz, Chase A; Brock, John H; Moseanko, Rod; Hawbecker, Stephanie; Pender, Roger; Cruzen, Christina L; Iaci, Jennifer F; Caggiano, Anthony O; Blight, Andrew R; Haenzi, Barbara; Huie, J Russell; Havton, Leif A; Nout-Lomas, Yvette S; Fawcett, James W; Ferguson, Adam R; Beattie, Michael S; Bresnahan, Jacqueline C; Tuszynski, Mark H.
Afiliación
  • Rosenzweig ES; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Salegio EA; California National Primate Research Center, University of California, Davis, Davis, CA, USA.
  • Liang JJ; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Weber JL; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Weinholtz CA; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Brock JH; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Moseanko R; Veterans Administration Medical Center, La Jolla, CA, USA.
  • Hawbecker S; California National Primate Research Center, University of California, Davis, Davis, CA, USA.
  • Pender R; California National Primate Research Center, University of California, Davis, Davis, CA, USA.
  • Cruzen CL; California National Primate Research Center, University of California, Davis, Davis, CA, USA.
  • Iaci JF; California National Primate Research Center, University of California, Davis, Davis, CA, USA.
  • Caggiano AO; Acorda Therapeutics, Ardsley, NY, USA.
  • Blight AR; Acorda Therapeutics, Ardsley, NY, USA.
  • Haenzi B; Acorda Therapeutics, Ardsley, NY, USA.
  • Huie JR; Cambridge University, Cambridge, UK.
  • Havton LA; Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
  • Nout-Lomas YS; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Fawcett JW; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Ferguson AR; College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Beattie MS; Cambridge University, Cambridge, UK.
  • Bresnahan JC; Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
  • Tuszynski MH; Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Nat Neurosci ; 22(8): 1269-1275, 2019 08.
Article en En | MEDLINE | ID: mdl-31235933
ABSTRACT
Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The enzyme chondroitinase (Chase) degrades inhibitory chondroitin sulfate proteoglycans and improves axonal sprouting and functional recovery after spinal cord injury in rodents. We evaluated the effects of Chase in rhesus monkeys that had undergone C7 spinal cord hemisection. Four weeks after hemisection, we administered multiple intraparenchymal Chase injections below the lesion, targeting spinal cord circuits that control hand function. Hand function improved significantly in Chase-treated monkeys relative to vehicle-injected controls. Moreover, Chase significantly increased corticospinal axon growth and the number of synapses formed by corticospinal terminals in gray matter caudal to the lesion. No detrimental effects were detected. This approach appears to merit clinical translation in spinal cord injury.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Condroitinasas y Condroitín Liasas Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Condroitinasas y Condroitín Liasas Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos