Interpretation of Whole-Genome Sequencing for Enteric Disease Surveillance and Outbreak Investigation.
Foodborne Pathog Dis
; 16(7): 504-512, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-31246502
ABSTRACT
The routine use of whole-genome sequencing (WGS) as part of enteric disease surveillance is substantially enhancing our ability to detect and investigate outbreaks and to monitor disease trends. At the same time, it is revealing as never before the vast complexity of microbial and human interactions that contribute to outbreak ecology. Since WGS analysis is primarily used to characterize and compare microbial genomes with the goal of addressing epidemiological questions, it must be interpreted in an epidemiological context. In this article, we identify common challenges and pitfalls encountered when interpreting sequence data in an enteric disease surveillance and investigation context, and explain how to address them.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Salud Pública
/
Epidemiología Molecular
/
Enfermedades Transmitidas por los Alimentos
/
Secuenciación Completa del Genoma
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Humans
Idioma:
En
Revista:
Foodborne Pathog Dis
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
MICROBIOLOGIA
/
PARASITOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Georgia