Zika autoimmunity and Guillain-Barré syndrome.
Curr Opin Rheumatol
; 31(5): 484-487, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31246623
ABSTRACT
PURPOSE OF REVIEW To summarize the recent data regarding Guillain-Barré syndrome (GBS) as an autoimmune disorder following infection with Zika virus (ZIKV) infection, including the proposed pathogenic mechanisms and the role of autoantibodies. RECENT FINDINGS:
The loss of self-tolerance that leads to autoimmune diseases is a multifactorial process that may be illustrated as 'the mosaic of autoimmunity'. Infectious agents may contribute to the development of autoimmunity by several proposed mechanisms. One of the central mechanisms is molecular mimicry, which is also the most plausible mechanism in the case of ZIKV-induced autoimmune disorders.A recent meta-analysis found a low prevalence of GBS associated with ZIKV infection. Nevertheless, the estimated cost of illness for patients with GBS associated with ZIKV are tremendous and exceed 4.7 million dollars per year in Brazil alone.SUMMARY:
Currently, there is sufficient data to indicate that ZIKV infection is one of many triggers and factors that may contribute to the development GBS. Thus, it is advised to evaluate and determine ZIKV exposure and infection in the management of potential GBS patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Autoinmunidad
/
Síndrome de Guillain-Barré
/
Virus Zika
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Infección por el Virus Zika
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Tolerancia Inmunológica
/
Anticuerpos Antivirales
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Opin Rheumatol
Asunto de la revista:
REUMATOLOGIA
Año:
2019
Tipo del documento:
Article