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Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Ponzetta, Andrea; Carriero, Roberta; Carnevale, Silvia; Barbagallo, Marialuisa; Molgora, Martina; Perucchini, Chiara; Magrini, Elena; Gianni, Francesca; Kunderfranco, Paolo; Polentarutti, Nadia; Pasqualini, Fabio; Di Marco, Sabrina; Supino, Domenico; Peano, Clelia; Cananzi, Ferdinando; Colombo, Piergiuseppe; Pilotti, Silvana; Alomar, Suliman Yousef; Bonavita, Eduardo; Galdiero, Maria Rosaria; Garlanda, Cecilia; Mantovani, Alberto; Jaillon, Sebastien.
Afiliación
  • Ponzetta A; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Carriero R; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Carnevale S; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
  • Barbagallo M; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Molgora M; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
  • Perucchini C; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Magrini E; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Gianni F; Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
  • Kunderfranco P; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Polentarutti N; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
  • Pasqualini F; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
  • Di Marco S; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
  • Supino D; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy.
  • Peano C; Humanitas Clinical and Research Center, 20089 Rozzano, Italy; Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, 20089 Rozzano, Italy.
  • Cananzi F; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy; Surgical Oncology Unit, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy.
  • Colombo P; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Pilotti S; Pathology Department, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.
  • Alomar SY; Zoology Department College of Science, King Saud University, 12372 Riyadh, Saudi Arabia.
  • Bonavita E; Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4GT, UK.
  • Galdiero MR; Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80138 Naples, Italy.
  • Garlanda C; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy; Humanitas Clinical and Research Center, 20089 Rozzano, Italy.
  • Mantovani A; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy; Humanitas Clinical and Research Center, 20089 Rozzano, Italy; The William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: alberto.mantovani@humanitasresearch.it.
  • Jaillon S; Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy; Humanitas Clinical and Research Center, 20089 Rozzano, Italy. Electronic address: sebastien.jaillon@humanitasresearch.it.
Cell ; 178(2): 346-360.e24, 2019 07 11.
Article en En | MEDLINE | ID: mdl-31257026
ABSTRACT
Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-γ-dependent pathway of immune resistance, associated with polarization of a subset of CD4- CD8- unconventional αß T cells (UTCαß). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTCαß associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTCαß polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Linfocitos T / Resistencia a la Enfermedad / Neoplasias / Neutrófilos Límite: Animals / Humans / Male Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article País de afiliación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Linfocitos T / Resistencia a la Enfermedad / Neoplasias / Neutrófilos Límite: Animals / Humans / Male Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article País de afiliación: Italia