Superoxide dismutase mimetic nanoceria restrains cerulein induced acute pancreatitis.
Nanomedicine (Lond)
; 14(14): 1805-1825, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-31267840
ABSTRACT
Aim:
The present study was carried out to assess the effect of nanoceria (NC) on pancreatic inflammation caused by cerulein.Methods:
NC was characterized and in vitro studies were carried out in murine macrophages. The in vivo effects were tested on cerulein-induced pancreatitis.Results:
In vitro treatment with NC remarkably protected macrophages from lipopolysaccharide-induced inflammation and oxidative stress as evident from the results of 2',7'-dichlorofluorescin diacetate, JC-1 and MitoSox staining. In vivo treatment with NC showed potent superoxide dismutase and catalase mimetic activity, antipancreatitis activity and improved histology. Furthermore, it reduced the expression of p65-NF-κB and acetylation of histone H3 at lysine K14, K56 and K79 residues.Conclusion:
We for the first time, demonstrate that NC may be a promising candidate for the therapy of pancreatitis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Ceruletida
/
Cerio
/
Inflamación
Límite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2019
Tipo del documento:
Article
País de afiliación:
India