Pathogen reduced plasma products: a clinical practice scientific review from the AABB.
Transfusion
; 59(9): 2974-2988, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31268584
ABSTRACT
BACKGROUND:
A small body of literature assessing the efficacy and safety of pathogen reduced (PR) plasma has been published. STUDY DESIGN ANDMETHODS:
An AABB committee systematically reviewed the literature and graded the clinical trial evidence with the assistance of a GRADE expert.RESULTS:
Most studies identified were low quality and had a small sample size; in addition, efficacy and safety were monitored in many different ways making it difficult to quantify therapeutic benefit and risk. The data analyzed in this systematic review showed that pathogen inactivation did not adversely affect the efficacy of S/D or amotosalen plasma transfusions in any patient population studied. In addition, there were no significant safety issues for these patient populations, other than the specific contraindications noted in their respective package inserts.CONCLUSION:
Larger, well-designed trials are needed to further evaluate the efficacy and safety of all of the PR plasma products.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasma
/
Desinfección
/
Patógenos Transmitidos por la Sangre
/
Viabilidad Microbiana
/
Seguridad de la Sangre
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Transfusion
Año:
2019
Tipo del documento:
Article