HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C.
Rev Soc Bras Med Trop
; 52: e20170427, 2019 Jun 27.
Article
en En
| MEDLINE
| ID: mdl-31271612
ABSTRACT
INTRODUCTION:
HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC.METHODS:
PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients.RESULTS:
There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree.CONCLUSIONS:
The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Plaqueta Humana
/
Carcinoma Hepatocelular
/
Hepatitis C Crónica
/
Neoplasias Hepáticas
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil