In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide.

Kassem, Asmaa F; Moustafa, Gaber O; Nossier, Eman S; Khalaf, Hemat S; Mounier, Marwa M; Al-Yousef, Suliman A; Mahmoud, Sabry Y

In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N¹,N³-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide.

Kassem, Asmaa F; Moustafa, Gaber O; Nossier, Eman S; Khalaf, Hemat S; Mounier, Marwa M; Al-Yousef, Suliman A; Mahmoud, Sabry Y.

Afiliación

Kassem AF; a Department of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Division , National Research Centre , Giza , Egypt.
Moustafa GO; b Department of Peptide Chemistry, Chemical Industries Research Division , National Research Centre , Cairo , Egypt.
Nossier ES; c Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy (Girls) , Al-Azhar University , Cairo , Egypt.
Khalaf HS; d Department of Chemistry , College of Science and Arts, Jouf University , Al Qurayat , Saudi Arabia.
Mounier MM; e Chemical Industries Research Division, Department of Photochemistry , National Research Centre , Cairo , Egypt.
Al-Yousef SA; f Pharmaceutical and Drug Industries Research Division, Department of Pharmacognosy , National Research Centre , Giza , Egypt.
Mahmoud SY; g Department of Clinical Laboratory Science, College of Applied Medical Science , University of Hafr Al Batin , Hafr Al Batin , Saudi Arabia.

J Enzyme Inhib Med Chem ; 34(1): 1247-1258, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31286782

Asunto(s)

Aminoácidos/química; Antineoplásicos/farmacología; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Humanos; Simulación del Acoplamiento Molecular; Espectroscopía de Protones por Resonancia Magnética; Espectrometría de Masa por Ionización de Electrospray; Espectrofotometría Infrarroja; Relación Estructura-Actividad

Palabras clave

Isophthalamide; amino acids; anticancer activity; molecular docking; peptides

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aminoácidos / Antineoplásicos Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido

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