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NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial.
Bonvalot, Sylvie; Rutkowski, Piotr L; Thariat, Juliette; Carrère, Sébastien; Ducassou, Anne; Sunyach, Marie-Pierre; Agoston, Peter; Hong, Angela; Mervoyer, Augustin; Rastrelli, Marco; Moreno, Victor; Li, Rubi K; Tiangco, Béatrice; Herraez, Antonio Casado; Gronchi, Alessandro; Mangel, László; Sy-Ortin, Teresa; Hohenberger, Peter; de Baère, Thierry; Le Cesne, Axel; Helfre, Sylvie; Saada-Bouzid, Esma; Borkowska, Aneta; Anghel, Rodica; Co, Ann; Gebhart, Michael; Kantor, Guy; Montero, Angel; Loong, Herbert H; Vergés, Ramona; Lapeire, Lore; Dema, Sorin; Kacso, Gabriel; Austen, Lyn; Moureau-Zabotto, Laurence; Servois, Vincent; Wardelmann, Eva; Terrier, Philippe; Lazar, Alexander J; Bovée, Judith V M G; Le Péchoux, Cécile; Papai, Zsusanna.
Afiliación
  • Bonvalot S; Department of Surgery, Institut Curie, PSL Research University, Paris, France. Electronic address: sylvie.bonvalot@curie.fr.
  • Rutkowski PL; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute-Oncology Center, Institute of Oncology, Warsaw, Poland.
  • Thariat J; Department of Radiation Oncology, Centre François Baclesse, Caen, France; Department of Radiation Oncology, Centre Lacassagne, Nice, France.
  • Carrère S; Department of Surgical Oncology, Centre Regional De Lutte Contre Le Cancer Paul Lamarque, Montpellier, France.
  • Ducassou A; Department of Radiation Oncology, Institut Claudius Regaud (ICR), Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-O), Toulouse, France.
  • Sunyach MP; Department of Radiotherapy, Léon Bérard Cancer Center, Lyon, France.
  • Agoston P; Department of Radiation Oncology, Országos Onkologiai Intézet, Budapest, Hungary.
  • Hong A; Department of Radiation Oncology, Chris O'Brien Lifehouse and The University of Sydney, Camperdown, NSW, Australia.
  • Mervoyer A; Department of Radiation Oncology, Institut de Cancerologie de l'Ouest- Rene Gauducheau, Saint-Herblain, France.
  • Rastrelli M; Department of Surgical Oncology, Istituto Oncologico Veneto IRCCS, Padova, Italy.
  • Moreno V; Department of Medical Oncology, Hospital Fundación Jimenez Diaz, Madrid, Spain.
  • Li RK; Department of Medical Oncology, St Luke's Medical Center, Quezon City, Philippines.
  • Tiangco B; Department of Medical Oncology, The Medical City Cancer Center, Pasay City, Philippines.
  • Herraez AC; Department of Medical Oncology, Hospital Clinico Universitario San Carlos, Madrid, Spain.
  • Gronchi A; Department of Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Mangel L; Department of Oncotherapy, University of Pecs, Pecs, Hungary.
  • Sy-Ortin T; Department of Radiation Oncology, Benavides Cancer Institute, University of Santo Tomas Hospital, Manila, Philippines.
  • Hohenberger P; Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
  • de Baère T; Department of Interventional Radiology, Gustave Roussy-Cancer Campus, Villejuif, France.
  • Le Cesne A; Department of Medical Oncology, Gustave Roussy-Cancer Campus, Villejuif, France.
  • Helfre S; Department of Radiation Therapy, Institut Curie, PSL Research University, Paris, France.
  • Saada-Bouzid E; Department of Medical Oncology, Centre Anticancer Antoine Lacassagne, Nice, France.
  • Borkowska A; Department of Radiotherapy, Maria Sklodowska-Curie Institute-Oncology Center, Institute of Oncology, Warsaw, Poland.
  • Anghel R; Institutul Oncologic Bucuresti Prof Dr Alexandru Trestioreanu, Bucharest, Romania.
  • Co A; Cebu Cancer Institute, Perpetual Succour Hospital, Cebu City, Philippines.
  • Gebhart M; Department of Orthopedic Surgery, ULB, Institut Jules Bordet, Brussels, Belgium.
  • Kantor G; Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France.
  • Montero A; Radiation Oncology Department, Hospital HM Universitario Sanchinarro, Madrid, Spain.
  • Loong HH; Department of Clinical Oncology, Prince of Wales Hospital, Sha Tin, Hong Kong.
  • Vergés R; Radiation Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Lapeire L; Department of Medical Oncology, Ghent University Hospital, Gent, Belgium.
  • Dema S; Municipal Emergency Hospital Timisoara, Timisoara, Romania.
  • Kacso G; Iuliu Hatieganu Medical University, RTC Amethyst, Cluj, Romania.
  • Austen L; Department of Radiation Oncology, Canberra Region Cancer Centre, Garran, Australia.
  • Moureau-Zabotto L; Department of Radiation-Oncology, Institut Paoli Calmettes, Marseille Cedex, France.
  • Servois V; Department of Radiology, Institut Curie, PSL Research University, Paris, France.
  • Wardelmann E; Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
  • Terrier P; Gustave Roussy, Cancer Campus, Paris-Sud University, Villejuif, France.
  • Lazar AJ; Departments of Pathology & Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Bovée JVMG; Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.
  • Le Péchoux C; Department of Radiation Oncology, Gustave Roussy-Cancer Campus, Villejuif, France.
  • Papai Z; Medical Centre, Hungarian Defence Forces, Budapest, Hungary.
Lancet Oncol ; 20(8): 1148-1159, 2019 08.
Article en En | MEDLINE | ID: mdl-31296491
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Fármacos Sensibilizantes a Radiaciones / Sarcoma / Neoplasias de los Tejidos Blandos / Nanopartículas / Hafnio Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Fármacos Sensibilizantes a Radiaciones / Sarcoma / Neoplasias de los Tejidos Blandos / Nanopartículas / Hafnio Tipo de estudio: Clinical_trials / Guideline Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido