Synthesis, in vivo and in silico anticonvulsant activity studies of new derivatives of 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide.

El Kayal, Wassim Mokhamad; Shtrygol, Sergiy Yu; Zalevskyi, Sergiy V; Shark, Amjad Abu; Tsyvunin, Vadim V; Kovalenko, Sergiy M; Bunyatyan, Natalya D; Perekhoda, Lina O; Severina, Hanna I; Georgiyants, Victoriya A

Synthesis, in vivo and in silico anticonvulsant activity studies of new derivatives of 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide.

El Kayal, Wassim Mokhamad; Shtrygol, Sergiy Yu; Zalevskyi, Sergiy V; Shark, Amjad Abu; Tsyvunin, Vadim V; Kovalenko, Sergiy M; Bunyatyan, Natalya D; Perekhoda, Lina O; Severina, Hanna I; Georgiyants, Victoriya A.

Afiliación

El Kayal WM; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Shtrygol SY; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Zalevskyi SV; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Shark AA; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Tsyvunin VV; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Kovalenko SM; V.N.Karazin Kharkiv National University, 4 Svobody sq., Kharkiv, 61077, Ukraine; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 8 Trubeckaya, Moscow, 119991, Russia.
Bunyatyan ND; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University, 8 Trubeckaya, Moscow, 119991, Russia; Federal State Budgetary Institution "Scientific Centre for Expert Evaluation of Medicinal Products", Petrovsky boulevard 8. bld. 2, Moscow,
Perekhoda LO; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Severina HI; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine.
Georgiyants VA; National University of Pharmacy, 53, Pushkinskaya st., Kharkiv, 61002, Ukraine. Electronic address: vgeor@nuph.edu.ua.

Eur J Med Chem ; 180: 134-142, 2019 Oct 15.

Article en En | MEDLINE | ID: mdl-31302446

Asunto(s)

Acetamidas/farmacología; Anticonvulsivantes/farmacología; Quinolinas/farmacología; Convulsiones/tratamiento farmacológico; Acetamidas/síntesis química; Acetamidas/química; Animales; Anticonvulsivantes/síntesis química; Anticonvulsivantes/química; Relación Dosis-Respuesta a Droga; Femenino; Masculino; Ratones; Pruebas de Sensibilidad Microbiana; Simulación del Acoplamiento Molecular; Estructura Molecular; Quinolinas/síntesis química; Quinolinas/química; Relación Estructura-Actividad

Palabras clave

2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)acetamide; Anticonvulsant activity; Molecular docking; Synthesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolinas / Convulsiones / Acetamidas / Anticonvulsivantes Límite: Animals Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Francia

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