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Expanding the Organismal Proteostasis Network: Linking Systemic Stress Signaling with the Innate Immune Response.
Miles, Jay; Scherz-Shouval, Ruth; van Oosten-Hawle, Patricija.
Afiliación
  • Miles J; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK.
  • Scherz-Shouval R; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
  • van Oosten-Hawle P; School of Molecular and Cell Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK. Electronic address: p.vanoosten-hawle@leeds.ac.uk.
Trends Biochem Sci ; 44(11): 927-942, 2019 11.
Article en En | MEDLINE | ID: mdl-31303384
Stress response pathways regulate proteostasis and mitigate macromolecular damage to promote long-term cellular health. Intercellular signaling is an essential layer of systemic proteostasis in an organism and is facilitated via transcellular signaling molecules that orchestrate the activation of stress responses across tissues and organs. Accumulating evidence indicates that components of the immune response act as signaling factors that regulate the cell-non-autonomous proteostasis network. Here, we review emergent advances in our understanding of cell-non-autonomous regulators of proteostasis networks in multicellular settings, from the model organism, Caenorhabditis elegans, to humans. We further discuss how innate immune responses can be players of the organismal proteostasis network and discuss how both are linked in cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Proteostasis / Inmunidad Innata Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Trends Biochem Sci Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Proteostasis / Inmunidad Innata Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Trends Biochem Sci Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido