Prognostic and clinicopathological significance of S100A14 expression in cancer patients: A meta-analysis.
Medicine (Baltimore)
; 98(28): e16356, 2019 Jul.
Article
en En
| MEDLINE
| ID: mdl-31305429
BACKGROUND: The prognostic significance of S100A14 for survival of cancer patients remains controversial. Therefore, we conducted this meta-analysis to explore the association between S100A14 expression and cancer prognosis. METHOD: Eligible studies were identified by searching the online databases Pubmed and EMBASE up to August 2018. Odds ratios (ORs) with 95% confidence intervals (CIs) severed as the summarized statistics for clinicopathological assessments and hazard ratios (HRs) with 95% CIs were calculated to clarify the correlation between S100A14 expression and prognosis of different cancers. RESULTS: A total of 11 studies with 1651 cancer patients were enrolled. The results indicated that S100A14 expression was not significantly associated with overall survival (OS) in total various cancers (HRâ=â1.54, 95% CI:0.89-2.67, Pâ=â.121). Further subgroup analysis stratified by tumor type showed that elevated S100A14 expression was associated with poor OS in breast cancer (HRâ=â3.66, 95% CI: 1.75-7.62, Pâ<â.001) and in ovarian cancer patients (HRâ=â3.78, 95%CI: 1.63-8.73, Pâ=â.002). Interestingly, high S100A14 expression was correlated with poor tumor differentiation (ORâ=â2.51, 95% CI: 1.52-4.13, Pâ<â.001). However, there were no significant correlations between S100A14 expression and other clinicopathologic characteristics. Begg funnel plot and Egger test showed that no publication bias was detected. CONCLUSIONS: Our meta-analysis suggests that S100A14 overexpression might be a predictive biomarker for poor prognosis in patients with breast cancer and ovarian cancer. Large-scale studies are required to confirm these results.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al Calcio
/
Neoplasias
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Estados Unidos