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The onset of pediatric refractory status epilepticus is not distributed uniformly during the day.
Sánchez Fernández, Iván; Gaínza-Lein, Marina; Abend, Nicholas S; Amengual-Gual, Marta; Anderson, Anne; Arya, Ravindra; Brenton, J Nicholas; Carpenter, Jessica L; Chapman, Kevin E; Clark, Justice; Farias-Moeller, Raquel; Davis Gaillard, William; Glauser, Tracy A; Goldstein, Joshua; Goodkin, Howard P; Guerriero, Réjean M; Hecox, Kurt; Jackson, Michele; Kapur, Kush; Kelley, Sarah A; Kossoff, Eric H W; Lai, Yi-Chen; McDonough, Tiffani L; Mikati, Mohamad A; Morgan, Lindsey A; Novotny, Edward J; Ostendorf, Adam P; Payne, Eric T; Peariso, Katrina; Piantino, Juan; Riviello, James J; Sannagowdara, Kumar; Stafstrom, Carl E; Tasker, Robert C; Tchapyjnikov, Dmitry; Topjian, Alexis A; Vasquez, Alejandra; Wainwright, Mark S; Wilfong, Angus; Williams, Korwyn; Loddenkemper, Tobias.
Afiliación
  • Sánchez Fernández I; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Child Neurology, Hospital Sant Joan de Déu, Universidad de Barcelona, Barcelona, Spain.
  • Gaínza-Lein M; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
  • Abend NS; Division of Neurology, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Amengual-Gual M; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Pediatric Neurology Unit, Department of Pediatrics, Hospital Universitari Son Espases, Universitat de les Illes Balears, Palma, Spain.
  • Anderson A; Section of Neurology and Developmental Neuroscience, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
  • Arya R; Division of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Brenton JN; Department of Neurology and Pediatrics, University of Virginia Health System, Charlottesville, VA, USA.
  • Carpenter JL; Center for Neuroscience, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Chapman KE; Departments of Pediatrics and Neurology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
  • Clark J; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Farias-Moeller R; Department of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Davis Gaillard W; Center for Neuroscience, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Glauser TA; Division of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Goldstein J; Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Goodkin HP; Department of Neurology and Pediatrics, University of Virginia Health System, Charlottesville, VA, USA.
  • Guerriero RM; Division of Pediatric and Developmental Neurology, Departments of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Hecox K; Department of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Jackson M; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kapur K; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kelley SA; Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USA.
  • Kossoff EHW; Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USA.
  • Lai YC; Section of Neurology and Developmental Neuroscience, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
  • McDonough TL; Division of Child Neurology, Department of Neurology, Columbia University Medical Center, Columbia University, New York, NY, USA.
  • Mikati MA; Division of Pediatric Neurology, Duke University Medical Center, Duke University, Durham, NC, USA.
  • Morgan LA; Departments of Pediatrics and Neurology, Seattle Children's Hospital, University of Washington, and Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
  • Novotny EJ; Departments of Pediatrics and Neurology, Seattle Children's Hospital, University of Washington, and Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
  • Ostendorf AP; Department of Neurology, Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.
  • Payne ET; Department of Neurology, Mayo Clinic, Mayo Clinic School of Medicine, Rochester, MN, USA.
  • Peariso K; Division of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
  • Piantino J; Department of Neurology, Doernbercher Children's Hospital, Oregon Health & Science University, Portland, OR, USA.
  • Riviello JJ; Section of Neurology and Developmental Neuroscience, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.
  • Sannagowdara K; Department of Pediatric Neurology, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Stafstrom CE; Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USA.
  • Tasker RC; Department of Neurology, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Tchapyjnikov D; Division of Pediatric Neurology, Duke University Medical Center, Duke University, Durham, NC, USA.
  • Topjian AA; Division of Critical Care Medicine, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Vasquez A; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Wainwright MS; Departments of Pediatrics and Neurology, Seattle Children's Hospital, University of Washington, and Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
  • Wilfong A; Barrow Neurological Institute, Phoenix Children's Hospital, Department of Pediatrics, University of Arizona School of Medicine, Phoenix, AZ, USA.
  • Williams K; Barrow Neurological Institute, Phoenix Children's Hospital, Department of Pediatrics, University of Arizona School of Medicine, Phoenix, AZ, USA.
  • Loddenkemper T; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: tobias.loddenkemper@childrens.harvard.edu.
Seizure ; 70: 90-96, 2019 Aug.
Article en En | MEDLINE | ID: mdl-31323566
ABSTRACT

PURPOSE:

To evaluate whether the onset of pediatric refractory status epilepticus (rSE) is related to time of day.

METHOD:

We analyzed the time of day for the onset of rSE in this prospective observational study performed from June 2011 to May 2019 in pediatric patients (1 month to 21 years of age). We evaluated the temporal distribution of pediatric rSE utilizing a cosinor analysis. We calculated the midline estimating statistic of rhythm (MESOR) and amplitude. MESOR is the estimated mean number of rSE episodes per hour if they were evenly distributed. Amplitude is the difference between MESOR and maximum rSE episodes/hour, or between MESOR and minimum rSE episodes/hour. We also evaluated the temporal distribution of time to treatment.

RESULTS:

We analyzed 368 patients (58% males) with a median (p25 - p75) age of 4.2 (1.3-9.7) years. The MESOR was 15.3 (95% CI 13.9-16.8) and the amplitude was 3.2 (95% CI 1.1-5.3), p = 0.0024, demonstrating that the distribution is not uniform, but better described as varying throughout the day with a peak in the morning (11am-12 pm) and trough at night (11 pm-12 am). The duration from rSE onset to application of the first non-benzodiazepine antiseizure medication peaked during the early morning (2am-3 am) with a minimum during the afternoon (2 pm-3 pm) (p = 0.0179).

CONCLUSIONS:

The distribution of rSE onset is not uniform during the day. rSE onset shows a 24-h distribution with a peak in the mid-morning (11am-12 pm) and a trough at night (11 pm-12am).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Epiléptico / Fotoperiodo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Seizure Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: España
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Epiléptico / Fotoperiodo Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Seizure Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: España