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Clinical Trial in a Dish: Personalized Stem Cell-Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT-Prolonging Drugs.
Blinova, Ksenia; Schocken, Derek; Patel, Dakshesh; Daluwatte, Chathuri; Vicente, Jose; Wu, Joseph C; Strauss, David G.
Afiliación
  • Blinova K; Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Schocken D; Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Patel D; Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Daluwatte C; Center for Drug Evaluation and Research, Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Vicente J; Center for Drug Evaluation and Research, Office of New Drugs, US Food and Drug Administration, Silver Spring, Maryland, USA.
  • Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
  • Strauss DG; Center for Drug Evaluation and Research, Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland, USA.
Clin Transl Sci ; 12(6): 687-697, 2019 11.
Article en En | MEDLINE | ID: mdl-31328865
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de QT Prolongado / Potenciales de Acción / Pruebas de Toxicidad / Miocitos Cardíacos / Cultivo Primario de Células Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Transl Sci Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de QT Prolongado / Potenciales de Acción / Pruebas de Toxicidad / Miocitos Cardíacos / Cultivo Primario de Células Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Clin Transl Sci Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos