Genetic diversity of HLA system in seven populations from Veracruz, Mexico: Veracruz city, Coatzacoalcos, Córdoba, Orizaba, Poza Rica, Xalapa and rural Veracruz.
Hum Immunol
; 81(9): 531-534, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-31345695
ABSTRACT
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1113 Mexicans from the state of Veracruz living in the cities of Coatzacoalcos (Nâ¯=â¯55), Orizaba (Nâ¯=â¯60), Córdoba (Nâ¯=â¯56), Poza Rica (Nâ¯=â¯45), Veracruz (Nâ¯=â¯171), Xalapa (Nâ¯=â¯187) and rural communities (Nâ¯=â¯539) to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes include 12 Native American haplotypes. Admixture estimates revealed that the main genetic components are Native American (64.93⯱â¯1.27% by ML; 55.10% of Native American haplotypes) and European (26.56⯱â¯0.89% by ML; 28.38% of European haplotypes), and a relatively high African genetic component (8.52⯱â¯1.82% by ML; 8.78% of African haplotypes).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Variación Genética
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Etnicidad
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Genética de Población
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Antígenos HLA
Límite:
Humans
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Hum Immunol
Año:
2020
Tipo del documento:
Article