Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.

Fujita, Masahide; Scheffer, Débora da Luz; Turnes, Bruna Lenfers; Cronin, Shane J F; Latrémolière, Alban; Costigan, Michael; Woolf, Clifford J; Latini, Alexandra; Andrews, Nick A

Fujita, Masahide; Scheffer, Débora da Luz; Turnes, Bruna Lenfers; Cronin, Shane J F; Latrémolière, Alban; Costigan, Michael; Woolf, Clifford J; Latini, Alexandra; Andrews, Nick A.

Afiliación

Fujita M; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Scheffer DDL; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Turnes BL; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Cronin SJF; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, and Academy of Sciences, Vienna, Austria.
Latrémolière A; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Costigan M; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Woolf CJ; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Latini A; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Andrews NA; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Arthritis Rheumatol ; 72(1): 57-66, 2020 01.

Article en En | MEDLINE | ID: mdl-31350812

Asunto(s)

Oxidorreductasas de Alcohol/antagonistas & inhibidores; Antirreumáticos/farmacología; Artritis Experimental/fisiopatología; Hiperestesia/fisiopatología; Articulaciones/efectos de los fármacos; Umbral del Dolor/efectos de los fármacos; Pterinas/orina; Sulfasalazina/farmacología; Adulto; Animales; Artritis Experimental/patología; Biomarcadores/orina; Biopterinas/análogos & derivados; Biopterinas/orina; Cromatografía Líquida de Alta Presión; Frío; Femenino; Miembro Posterior; Calor; Humanos; Articulaciones/patología; Masculino; Ratones

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Pterinas / Sulfasalazina / Umbral del Dolor / Antirreumáticos / Oxidorreductasas de Alcohol / Hiperestesia / Articulaciones Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Arthritis Rheumatol Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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