Your browser doesn't support javascript.
loading
Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.
Lind, Abigail L; Lai, Yvonne Y Y; Mostovoy, Yulia; Holloway, Alisha K; Iannucci, Alessio; Mak, Angel C Y; Fondi, Marco; Orlandini, Valerio; Eckalbar, Walter L; Milan, Massimo; Rovatsos, Michail; Kichigin, Ilya G; Makunin, Alex I; Johnson Pokorná, Martina; Altmanová, Marie; Trifonov, Vladimir A; Schijlen, Elio; Kratochvíl, Lukás; Fani, Renato; Velenský, Petr; Rehák, Ivan; Patarnello, Tomaso; Jessop, Tim S; Hicks, James W; Ryder, Oliver A; Mendelson, Joseph R; Ciofi, Claudio; Kwok, Pui-Yan; Pollard, Katherine S; Bruneau, Benoit G.
Afiliación
  • Lind AL; Gladstone Institutes, San Francisco, CA, USA.
  • Lai YYY; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
  • Mostovoy Y; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
  • Holloway AK; Gladstone Institutes, San Francisco, CA, USA.
  • Iannucci A; Department of Biology, University of Florence, Sesto Fiorentino, Italy.
  • Mak ACY; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
  • Fondi M; Department of Biology, University of Florence, Sesto Fiorentino, Italy.
  • Orlandini V; Department of Biology, University of Florence, Sesto Fiorentino, Italy.
  • Eckalbar WL; Institute for Human Genetics, University of California, San Francisco, CA, USA.
  • Milan M; Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy.
  • Rovatsos M; Department of Ecology, Charles University, Prague, Czech Republic.
  • Kichigin IG; Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Libechov, Czech Republic.
  • Makunin AI; Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia.
  • Johnson Pokorná M; Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia.
  • Altmanová M; Department of Ecology, Charles University, Prague, Czech Republic.
  • Trifonov VA; Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Libechov, Czech Republic.
  • Schijlen E; Department of Ecology, Charles University, Prague, Czech Republic.
  • Kratochvíl L; Institute of Animal Physiology and Genetics, The Czech Academy of Sciences, Libechov, Czech Republic.
  • Fani R; Institute of Molecular and Cellular Biology SB RAS, Novosibirsk, Russia.
  • Velenský P; B.U. Bioscience, Wageningen University, Wageningen, The Netherlands.
  • Rehák I; Department of Ecology, Charles University, Prague, Czech Republic.
  • Patarnello T; Department of Biology, University of Florence, Sesto Fiorentino, Italy.
  • Jessop TS; Prague Zoological Garden, Prague, Czech Republic.
  • Hicks JW; Prague Zoological Garden, Prague, Czech Republic.
  • Ryder OA; Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy.
  • Mendelson JR; Centre for Integrative Ecology, Deakin University, Waurn Ponds, Victoria, Australia.
  • Ciofi C; Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine, CA, USA.
  • Kwok PY; Institute for Conservation Research, San Diego Zoo, Escondido, CA, USA.
  • Pollard KS; Zoo Atlanta, Atlanta, GA, USA.
  • Bruneau BG; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Nat Ecol Evol ; 3(8): 1241-1252, 2019 08.
Article en En | MEDLINE | ID: mdl-31358948
ABSTRACT
Monitor lizards are unique among ectothermic reptiles in that they have high aerobic capacity and distinctive cardiovascular physiology resembling that of endothermic mammals. Here, we sequence the genome of the Komodo dragon Varanus komodoensis, the largest extant monitor lizard, and generate a high-resolution de novo chromosome-assigned genome assembly for V. komodoensis using a hybrid approach of long-range sequencing and single-molecule optical mapping. Comparing the genome of V. komodoensis with those of related species, we find evidence of positive selection in pathways related to energy metabolism, cardiovascular homoeostasis, and haemostasis. We also show species-specific expansions of a chemoreceptor gene family related to pheromone and kairomone sensing in V. komodoensis and other lizard lineages. Together, these evolutionary signatures of adaptation reveal the genetic underpinnings of the unique Komodo dragon sensory and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Komodo dragons evade the anticoagulant effects of their own saliva. The Komodo dragon genome is an important resource for understanding the biology of monitor lizards and reptiles worldwide.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Cardiovascular / Lagartos Límite: Animals Idioma: En Revista: Nat Ecol Evol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Cardiovascular / Lagartos Límite: Animals Idioma: En Revista: Nat Ecol Evol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos