Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma.

Banerjee, Sudeep; Corless, Christopher L; Miettinen, Markku M; Noh, Sangkyu; Ustoy, Rowan; Davis, Jessica L; Tang, Chih-Min; Yebra, Mayra; Burgoyne, Adam M; Sicklick, Jason K

Banerjee, Sudeep; Corless, Christopher L; Miettinen, Markku M; Noh, Sangkyu; Ustoy, Rowan; Davis, Jessica L; Tang, Chih-Min; Yebra, Mayra; Burgoyne, Adam M; Sicklick, Jason K.

Afiliación

Banerjee S; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Corless CL; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Miettinen MM; Department of Pathology and Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Noh S; Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.
Ustoy R; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Davis JL; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Tang CM; Department of Pathology and Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
Yebra M; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Burgoyne AM; Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, San Diego, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Sicklick JK; Division of Hematology Oncology, Department of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.

J Transl Med ; 17(1): 246, 2019 07 30.

Article en En | MEDLINE | ID: mdl-31362756

Asunto(s)

Fibroma/genética; Genes Supresores de Tumor; Receptor Patched-1/genética; ARN Largo no Codificante/genética; Adolescente; Adulto; Anciano; Proteínas Portadoras/genética; Deleción Cromosómica; Ciclina D1/genética; Exones; Femenino; Proteínas Hedgehog/genética; Secuenciación de Nucleótidos de Alto Rendimiento; Humanos; Masculino; Glicoproteínas de Membrana/genética; Persona de Mediana Edad; Estudios Retrospectivos; Receptor Smoothened/genética; Adulto Joven; Proteína con Dedos de Zinc GLI1/genética

Palabras clave

GLI1; Gastric mass; Gastrointestinal stromal tumor; Hedgehog pathway; Next generation sequencing; Patched 1; SMO inhibitor; Sonidegib; Submucosal tumor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genes Supresores de Tumor / Fibroma / ARN Largo no Codificante / Receptor Patched-1 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Transl Med Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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