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Risk Analysis for Chemotherapy-induced Nausea and Vomiting (CINV) in Patients Receiving FEC100 Treatment.
Hayashi, Mitsuhiro; Nakazawa, Kyoko; Hasegawa, Yoshie; Horiguchi, Jun; Miura, Daishu; Ishikawa, Takashi; Takao, Shintaro; Kim, Seung Jim; Yamagami, Kazuhiko; Miyashita, Masaru; Konishi, Muneharu; Shigeoka, Yasushi; Suzuki, Masato; Taguchi, Tetsuya; Kubota, Tomoyuki; Tanino, Hirokazu; Yamada, Kimito; Narui, Kazutaka; Kimura, Konomi; Akazawa, Kohei; Kohno, Norio.
Afiliación
  • Hayashi M; Breast Center, Dokkyo Medical University, Tochigi, Japan hayashim@dokkyomed.ac.jp.
  • Nakazawa K; Department of Medical Informatics, Niigata University, Niigata, Japan.
  • Hasegawa Y; Department of Breast Surgery, Hirosaki Municipal Hospital, Hirosaki, Japan.
  • Horiguchi J; Department of Breast Surgery, International University of Health and Welfare, Chiba, Japan.
  • Miura D; Akasaka Miura Clinic, Tokyo, Japan.
  • Ishikawa T; Department of Breast Oncology, Tokyo Medical University, Tokyo, Japan.
  • Takao S; Department of Breast Surgery, Hyogo Cancer Center, Hyogo, Japan.
  • Kim SJ; Department of Breast and Endocrine Surgery, Osaka University, Osaka, Japan.
  • Yamagami K; Department of Breast Oncology, Shinko Hospital, Hyogo, Japan.
  • Miyashita M; Department of Surgery, Kohnan Hospital, Hyogo, Japan.
  • Konishi M; Department of Surgery, Hyogo Prefectural Nishinomiya Hospital, Hyogo, Japan.
  • Shigeoka Y; Department of Medical Oncology, Yodogawa Christian Hospital, Osaka, Japan.
  • Suzuki M; Department of Surgery, National Hospital Organization Chiba Medical Center, Chiba, Japan.
  • Taguchi T; Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Kubota T; Department of Surgery, Kamiiida Daiichi General Hospital, Aichi, Japan.
  • Tanino H; Department of Surgery, Kobe University, Hyogo, Japan.
  • Yamada K; Department of Breast Oncology, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan.
  • Narui K; Department of Breast and Endocrine Surgery, Yokohama City University Medical Center, Kanagawa, Japan.
  • Kimura K; Department of Medical Informatics, Niigata University, Niigata, Japan.
  • Akazawa K; Department of Medical Informatics, Niigata University, Niigata, Japan.
  • Kohno N; Department of Breast Surgery, Kobe Kaisei Hospital, Hyogo, Japan.
Anticancer Res ; 39(8): 4305-4314, 2019 Aug.
Article en En | MEDLINE | ID: mdl-31366522
ABSTRACT
BACKGROUND/

AIM:

Risk factors for chemotherapy-induced nausea and vomiting (CINV) with anthracycline-containing regimen for breast cancer patients remain unknown. The risk factors for CINV with FEC100 were investigated. PATIENTS AND

METHODS:

Data on CINV events and patient backgrounds of 180 patients were collected from the first cycle of FEC100 treatment. In this regimen, patients were administered various antiemetics (ADs). The combinations of ADs were classified into four categories, while body mass index (BMI) was stratified into three categories. Risk factors were selected based on patient characteristics and combination of ADs. Risks for CINV were analyzed by univariate and multivariate analyses.

RESULTS:

In the univariate analysis of nausea, BMI was a significant factor, while BMI and combination of ADs were significant in vomiting. In the multivariate analysis concerning nausea, BMI was a significant factor. In the analysis concerning vomiting, the combination of ADs and BMI were significant.

CONCLUSION:

BMI was the most important risk factor for nausea and vomiting, while the combination of ADs was for vomiting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vómitos / Neoplasias de la Mama / Náusea / Antineoplásicos Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 2019 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vómitos / Neoplasias de la Mama / Náusea / Antineoplásicos Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 2019 Tipo del documento: Article País de afiliación: Japón