Synthesis, in-vitro &#945;-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives.

Hussain, Fida; Khan, Zeeshan; Jan, Muhammad Saeed; Ahmad, Sajjad; Ahmad, Ashfaq; Rashid, Umer; Ullah, Farhat; Ayaz, Muhammad; Sadiq, Abdul

Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives.

Hussain, Fida; Khan, Zeeshan; Jan, Muhammad Saeed; Ahmad, Sajjad; Ahmad, Ashfaq; Rashid, Umer; Ullah, Farhat; Ayaz, Muhammad; Sadiq, Abdul.

Afiliación

Hussain F; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan; Department of Pharmacy, University of Swabi, KP, Pakistan.
Khan Z; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan.
Jan MS; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan.
Ahmad S; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan.
Ahmad A; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan.
Rashid U; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060 Abbottabad, Pakistan. Electronic address: umerrashid@cuiatd.edu.pk.
Ullah F; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan.
Ayaz M; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan.
Sadiq A; Department of Pharmacy, Faculty of Biological Sciences, University of Malakand, Chakdara 18000 Dir (L), KP, Pakistan. Electronic address: sadiquom@yahoo.com.

Bioorg Chem ; 91: 103128, 2019 10.

Article en En | MEDLINE | ID: mdl-31369977

Asunto(s)

Antioxidantes/uso terapéutico; Diabetes Mellitus Experimental/tratamiento farmacológico; Inhibidores de Glicósido Hidrolasas/uso terapéutico; Hipoglucemiantes/uso terapéutico; Succinimidas/uso terapéutico; Tiazolidinedionas/uso terapéutico; Aloxano; Animales; Antioxidantes/síntesis química; Antioxidantes/metabolismo; Dominio Catalítico; Inhibidores de Glicósido Hidrolasas/síntesis química; Inhibidores de Glicósido Hidrolasas/metabolismo; Hipoglucemiantes/síntesis química; Hipoglucemiantes/metabolismo; Ratones; Simulación del Acoplamiento Molecular; Estructura Molecular; Unión Proteica; Relación Estructura-Actividad; Succinimidas/síntesis química; Succinimidas/metabolismo; Tiazolidinedionas/síntesis química; Tiazolidinedionas/metabolismo; alfa-Glucosidasas/química; alfa-Glucosidasas/metabolismo

Palabras clave

Cyanoacetate; Pyrrolidine-2,5-dione; Succinimide; Thiazolidine-2,4-dione; α-Glucosidase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinimidas / Tiazolidinedionas / Diabetes Mellitus Experimental / Inhibidores de Glicósido Hidrolasas / Hipoglucemiantes / Antioxidantes Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos

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