Influenza A Virus Protein NS1 Exhibits Strain-Independent Conformational Plasticity.

Mitra, Sayantan; Kumar, Dilip; Hu, Liya; Sankaran, Banumathi; Moosa, Mahdi Muhammad; Rice, Andrew P; Ferreon, Josephine C; Ferreon, Allan Chris M; Prasad, B V Venkataram

Mitra, Sayantan; Kumar, Dilip; Hu, Liya; Sankaran, Banumathi; Moosa, Mahdi Muhammad; Rice, Andrew P; Ferreon, Josephine C; Ferreon, Allan Chris M; Prasad, B V Venkataram.

Afiliación

Mitra S; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Kumar D; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Hu L; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Sankaran B; Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Berkeley, California, USA.
Moosa MM; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Rice AP; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Ferreon JC; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Ferreon ACM; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.
Prasad BVV; The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA vprasad@bcm.edu.

J Virol ; 93(21)2019 11 01.

Article en En | MEDLINE | ID: mdl-31375595

Asunto(s)

Virus de la Influenza A/química; Proteínas no Estructurales Virales/química; Secuencia de Aminoácidos; Cristalografía por Rayos X; Transferencia Resonante de Energía de Fluorescencia; Virus de la Influenza A/clasificación; Virus de la Influenza A/genética; Ligandos; Mutación; Unión Proteica; Conformación Proteica; Relación Estructura-Actividad; Proteínas no Estructurales Virales/genética; Proteínas no Estructurales Virales/metabolismo

Palabras clave

H5N1; NS1; X-ray crystallography; antagonist; influenza virus; innate immune response; smFRET; structure

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Influenza A / Proteínas no Estructurales Virales Idioma: En Revista: J Virol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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