Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder.
Mitochondrion
; 48: 67-77, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31377247
ABSTRACT
We analyzed activities of complex I, II, III, and IV, and citrate synthase (CS) in patients with major depressive disorder (MDD) or Alzheimer's disease (AD) presenting with or without depression. Associations of these parameters with disease or disease severity were observed in both AD and MDD; however, mean values of mitochondrial parameters were significantly altered in AD but not in MDD. Potential mitochondrial dysfunction in MDD seems not to be caused by disturbed activity of CS or respiratory complexes. In AD, a decrease in the activity of CS and complex IV may cause mitochondrial dysfunction, whereas an increase in activities of other mitochondrial complexes or their ratios to CS may be an adaptive response. The data indicate that comorbid depression in AD is associated with increased complex II activity. The mitochondrial parameters measured can be included in the panel of biomarkers of AD.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Proteínas del Complejo de Cadena de Transporte de Electrón
/
Trastorno Depresivo Mayor
/
Transporte de Electrón
/
Enfermedad de Alzheimer
/
Mitocondrias
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mitochondrion
Año:
2019
Tipo del documento:
Article