From epithelial remodelling to carcinogenesis.
Prog Biophys Mol Biol
; 150: 203-205, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31381892
ABSTRACT
The novel cancer theory named 'the tissue organization field theory' (TOFT) suggests that carcinogenesis is a process analogous to embryonic development, whereby organs are formed through interactions among different cell types. The suggested 'morphological remodelling' of the epithelium under hypoxia in gut breathing fish (GBF) has many common features with carcinogenesis. It appears that research into the relationship among epidermal growth factor receptor (EGFR), hypoxia inducible factor (HIF) as well as hypoxia and normoxia states in GBF fishes can be crucial in learning about the steering mechanisms of squamous epithelium proliferation, leading to a better understanding of carcinogenesis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipoxia de la Célula
/
Células Epiteliales
/
Factor 1 Inducible por Hipoxia
/
Carcinogénesis
/
Receptores ErbB
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Biophys Mol Biol
Año:
2020
Tipo del documento:
Article