Whole genome and transcriptome sequencing of post-mortem cardiac tissues from sudden cardiac death victims identifies a gene regulatory variant in NEXN.

Andersen, Jeppe D; Jacobsen, Stine B; Trudsø, Linea C; Kampmann, Marie-Louise; Banner, Jytte; Morling, Niels

Andersen, Jeppe D; Jacobsen, Stine B; Trudsø, Linea C; Kampmann, Marie-Louise; Banner, Jytte; Morling, Niels.

Afiliación

Andersen JD; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. jeppe.dyrberg.andersen@sund.ku.dk.
Jacobsen SB; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Trudsø LC; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kampmann ML; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Banner J; Section of Forensic Pathology, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Morling N; Section of Forensic Genetics, Department of Forensic Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Int J Legal Med ; 133(6): 1699-1709, 2019 Nov.

Article en En | MEDLINE | ID: mdl-31392414

Asunto(s)

Muerte Súbita Cardíaca/etiología; Secuenciación del Exoma; Perfilación de la Expresión Génica; Variación Genética; Proteínas de Microfilamentos/genética; Transcriptoma; Adulto; Cardiomiopatía Hipertrófica/genética; Femenino; Humanos; Lactante; Recién Nacido; Masculino; Persona de Mediana Edad; Miocardio/patología; Cambios Post Mortem; Programas Informáticos; Muerte Súbita del Lactante/etiología

Palabras clave

Genetics; Molecular autopsy; NEXN; RNA; Sudden arrhythmic death syndrome; Sudden cardiac death

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Muerte Súbita Cardíaca / Perfilación de la Expresión Génica / Transcriptoma / Secuenciación del Exoma / Proteínas de Microfilamentos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Infant / Male / Middle aged / Newborn Idioma: En Revista: Int J Legal Med Asunto de la revista: JURISPRUDENCIA Año: 2019 Tipo del documento: Article País de afiliación: Dinamarca

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