Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment.
Life Sci
; 233: 116733, 2019 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-31394127
ABSTRACT
Exosomes are extracellular vesicles with the size of 40-100â¯nm in diameter and a density of 1.13-1.19â¯g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the recipient cells biochemical features through biomolecules delivery and play a role in cellular communication. These vesicles are produced from body fluids and different cell types like mesenchymal stem cells (MSCs). Evidence suggests that mesenchymal stem cells-derived exosome (MSC-EXO) exhibit functions similar to MSCs with low immunogenicity and no tumorization. MSCs can also be isolated from a variety of sources including human umbilical cord (HUC). Because of the non-invasive collection method, higher proliferation and lower immunogenicity, HUCMSC-EXO has been frequently used in regenerative medicine and various diseases treatment compared to the other MSC-EXO resources. This review aimed to investigate the applications of HUCMSC-EXO in different diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cordón Umbilical
/
Enfermedad
/
Trasplante de Células Madre Mesenquimatosas
/
Medicina Regenerativa
/
Exosomas
/
Células Madre Mesenquimatosas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Life Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Irán