Inhibition of integrin &#945;<sub>D</sub>ß<sub>2</sub>-mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation.

Cui, Kui; Podolnikova, Nataly P; Bailey, William; Szmuc, Eric; Podrez, Eugene A; Byzova, Tatiana V; Yakubenko, Valentin P

Inhibition of integrin α_Dß₂-mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation.

Cui, Kui; Podolnikova, Nataly P; Bailey, William; Szmuc, Eric; Podrez, Eugene A; Byzova, Tatiana V; Yakubenko, Valentin P.

Afiliación

Cui K; Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614.
Podolnikova NP; Center for Metabolic and Vascular Biology, School of Life Sciences, Arizona State University, Tempe, Arizona 85281.
Bailey W; Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614.
Szmuc E; Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614.
Podrez EA; Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44106.
Byzova TV; Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44106.
Yakubenko VP; Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614 yakubenko@etsu.edu.

J Biol Chem ; 294(39): 14370-14382, 2019 09 27.

Article en En | MEDLINE | ID: mdl-31395659

Asunto(s)

Antiinflamatorios/farmacología; Movimiento Celular; Macrófagos Peritoneales/metabolismo; Péptidos Cíclicos/farmacología; Peritonitis/tratamiento farmacológico; Pirroles/metabolismo; Animales; Antiinflamatorios/uso terapéutico; Células Cultivadas; Células HEK293; Humanos; Cadenas alfa de Integrinas/metabolismo; Macrófagos Peritoneales/efectos de los fármacos; Macrófagos Peritoneales/fisiología; Ratones; Ratones Endogámicos C57BL; Péptidos Cíclicos/uso terapéutico; Peritonitis/etiología; Unión Proteica; Tioglicolatos/toxicidad

Palabras clave

adhesion; inflammation; integrin; integrin αDß2; macrophage; migration

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Peritonitis / Pirroles / Movimiento Celular / Macrófagos Peritoneales / Antiinflamatorios Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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