RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres.

Barroso-González, Jonathan; García-Expósito, Laura; Hoang, Song My; Lynskey, Michelle L; Roncaioli, Justin L; Ghosh, Arundhati; Wallace, Callen T; de Vitis, Marco; Modesti, Mauro; Bernstein, Kara A; Sarkar, Saumendra N; Watkins, Simon C; O'Sullivan, Roderick J

Barroso-González, Jonathan; García-Expósito, Laura; Hoang, Song My; Lynskey, Michelle L; Roncaioli, Justin L; Ghosh, Arundhati; Wallace, Callen T; de Vitis, Marco; Modesti, Mauro; Bernstein, Kara A; Sarkar, Saumendra N; Watkins, Simon C; O'Sullivan, Roderick J.

Afiliación

Barroso-González J; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
García-Expósito L; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Hoang SM; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Lynskey ML; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Roncaioli JL; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Ghosh A; Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Wallace CT; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
de Vitis M; Department of Science, University of Rome "ROMA TRE", 00146 Rome, Italy.
Modesti M; Cancer Research Center of Marseille, CNRS UMR7258, Inserm UMR1068, Aix Marseille Université U105; Institut Paoli Calmettes, 27 Boulevard Lei Roure CS30059, 13273 Marseille, Cedex 09, France.
Bernstein KA; Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Sarkar SN; Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Watkins SC; Department of Cell Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
O'Sullivan RJ; Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. Electronic address: osullivanr@upmc.edu.

Mol Cell ; 76(1): 11-26.e7, 2019 10 03.

Article en En | MEDLINE | ID: mdl-31400850

Asunto(s)

Proteínas de Unión al ADN/metabolismo; Neoplasias/metabolismo; Proteínas de Unión al ARN/metabolismo; Homeostasis del Telómero; Telómero/metabolismo; Autofagia; Proteína 7 Relacionada con la Autofagia/genética; Proteína 7 Relacionada con la Autofagia/metabolismo; Homólogo de la Proteína 1 Relacionada con la Autofagia/genética; Homólogo de la Proteína 1 Relacionada con la Autofagia/metabolismo; Proliferación Celular; ADN Polimerasa III/genética; ADN Polimerasa III/metabolismo; Proteínas de Unión al ADN/genética; Regulación Neoplásica de la Expresión Génica; Células HEK293; Células HeLa; Recombinación Homóloga; Humanos; Péptidos y Proteínas de Señalización Intracelular/genética; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Ligasas/genética; Ligasas/metabolismo; Lisina; Neoplasias/genética; Neoplasias/patología; Nucleotidiltransferasas/genética; Nucleotidiltransferasas/metabolismo; Estabilidad Proteica; Proteínas de Unión al ARN/genética; Proteína Recombinante y Reparadora de ADN Rad52/genética; Proteína Recombinante y Reparadora de ADN Rad52/metabolismo; Transducción de Señal; Sumoilación; Telómero/genética; Telómero/patología

Palabras clave

RAD51AP1; SUMOylation; autophagy; cancer; homology-directed repair; telomere

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Telómero / Proteínas de Unión al ARN / Proteínas de Unión al ADN / Homeostasis del Telómero / Neoplasias Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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