[Clinical Characteristics of Liver Dysfunction in Patients with Hemophagocytic Syndrome].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 27(4): 1297-1304, 2019 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-31418396
ABSTRACT
OBJECTIVE:
To explore the clinical feature of liver injury in patients with hemophagocytic syndrome (HPS).METHODS:
The clinical data of 92 patients with HPS in our hospital were analyzed retrospectively, and the characteristics of hepatic lesion and its relationship with prognosis in HPS patients were explored.RESULT:
92 cases of HPS showed different degrees of liver dysfunction from mild to moderate. The clinical parameters of liver dysfunction included the increased level of LDH (89.13%), AST (64.13%), TBIL (59.78%) and decreased level of ALB (90.22%). Moreover, 76.09% and 67.39% of the patients had the prolonging of APTT and PT respectively. The ALB level of patients in rheumatoid immune group were higher than that in infection, maglinancy and unexplained groups, all with statistically and significant difference (Pï¼0.05, Pï¼0.05 and Pï¼0.01), the ALB level of patients in infection group were statistically and significantly higher than that in unexplained group (Pï¼0.01). The Fbg level of patients in infection group were lower than that in maglinancy group, unexplained group and rheumatoid immune group, all the differences were statistically significant (Pï¼0.05, Pï¼0.01 and Pï¼0.05). Child-Pugh grading was further carried out in HPS patients with liver disfunction. Survival time of the patients grade A was significantly higher than that of grade B and C of patients. Univariate analysis showed that the patients with LDH≥2000 U/L, ALBï¼30 g/L and PT≥15.1 s had a survival time inferior to control patients (Pï¼0.05, Pï¼0.01 and Pï¼0.01, respectively). Multivariate analysis showed that ALBï¼30 g/L was an independent adverse prognostic factor for these patients (Pï¼0.01).CONCLUSION:
Patients with HPS generally have impaired liver function mainly manifested with elevated LDH and AST levels, and declined ALB level, which may correlate with the disease cause and prognosis. Patients with LDH≥2000 U/L, ALBï¼30 g/L and PT≥15.1 s have a poorer prognosis and should be treated as soon as possible.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfohistiocitosis Hemofagocítica
/
Hepatopatías
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Zh
Revista:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Asunto de la revista:
HEMATOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China