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Genomic sequencing of a national emm66 group A streptococci (GAS) outbreak among people who inject drugs and the homeless community in England and Wales, January 2016-May 2017.
Bubba, Laura; Bundle, Nick; Kapatai, Georgia; Daniel, Roger; Balasegaram, Sooria; Anderson, Charlotte; Chalker, Vicki; Lamagni, Theresa; Brown, Colin; Ready, Derren; Efstratiou, Androulla; Coelho, Juliana.
Afiliación
  • Bubba L; Bacteriology Reference Department, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK; European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Gustav III:s boulevard 40, 169 73 Solna, Stockholm, Sweden. Electronic ad
  • Bundle N; United Kingdom Field Epidemiology Training Programme, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK; Field Epidemiology Services, National Infection Service, Public Health England, Wellington, Waterloo Rd, Lambeth, London SE1 8UG, London, UK.
  • Kapatai G; Respiratory and Vaccine Preventable Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Daniel R; Respiratory and Vaccine Preventable Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Balasegaram S; United Kingdom Field Epidemiology Training Programme, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Anderson C; United Kingdom Field Epidemiology Training Programme, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Chalker V; Respiratory and Vaccine Preventable Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Lamagni T; Healthcare-Associated Infection & Antimicrobial Resistance Department, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Brown C; Respiratory and Vaccine Preventable Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Ready D; Respiratory and Vaccine Preventable Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Efstratiou A; Bacteriology Reference Department, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
  • Coelho J; Respiratory and Vaccine Preventable Bacteria Reference Unit, National Infection Service, Public Health England, 61 Colindale Avenue, NW9 5EQ London, UK.
J Infect ; 79(5): 435-443, 2019 11.
Article en En | MEDLINE | ID: mdl-31419474
ABSTRACT
An outbreak of an uncommon emm type (emm66.0) of group A streptococcus (GAS) occurred in England and Wales between January 2016 and May 2017, involving 52 individuals who were homeless or injecting drugs users. In order to investigate the outbreak, epidemiological and network analysis were performed; moreover 55 isolates (32 outbreak, 5 non-outbreak and 13 historical - 2005-2015) were tested with whole genome sequencing (WGS), antimicrobial resistance determination, Bayesian evolutionary analysis (BEAST). Forty one isolates (including 32 outbreak strains) belonged to a single emm66.0 clade (average SNP difference 6.6; range 0-16 SNPs) separate from the other isolates and two strains previously considered part of the outbreak (SNP average 5876; range 93-8417 SNPs). Antibiotic resistance was not detected in the outbreak clone. No common source of infection was identified. WGS confirmed expansion of an emm66.0 clone in a hard-to-reach population and enabled refinement of the initial case definition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Personas con Mala Vivienda / Proteínas Portadoras / Abuso de Sustancias por Vía Intravenosa / Brotes de Enfermedades / Infecciones Comunitarias Adquiridas / Antígenos Bacterianos Tipo de estudio: Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Infect Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Personas con Mala Vivienda / Proteínas Portadoras / Abuso de Sustancias por Vía Intravenosa / Brotes de Enfermedades / Infecciones Comunitarias Adquiridas / Antígenos Bacterianos Tipo de estudio: Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Infect Año: 2019 Tipo del documento: Article