A Revised Modular Approach to (-)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions.
European J Org Chem
; 2019(12): 2289-2296, 2019 Mar 31.
Article
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| MEDLINE
| ID: mdl-31423106
ABSTRACT
A revised modular approach to various synthetic (-)-trans-Δ8-THC derivatives through late-stage Suzuki-Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp2- and sp3-hybridized cross-coupling partners with minimal ß-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki-Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.
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01-internacional
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MEDLINE
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En
Revista:
European J Org Chem
Año:
2019
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Article