Discovery of certain benzyl/phenethyl thiazolidinone-indole hybrids as potential anti-proliferative agents: Synthesis, molecular modeling and tubulin polymerization inhibition study.

Sigalapalli, Dilep Kumar; Pooladanda, Venkatesh; Singh, Priti; Kadagathur, Manasa; Guggilapu, Sravanthi Devi; Uppu, Jaya Lakshmi; Tangellamudi, Neelima D; Gangireddy, Pavan Kumar; Godugu, Chandraiah; Bathini, Nagendra Babu

Sigalapalli, Dilep Kumar; Pooladanda, Venkatesh; Singh, Priti; Kadagathur, Manasa; Guggilapu, Sravanthi Devi; Uppu, Jaya Lakshmi; Tangellamudi, Neelima D; Gangireddy, Pavan Kumar; Godugu, Chandraiah; Bathini, Nagendra Babu.

Afiliación

Sigalapalli DK; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Pooladanda V; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Singh P; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Kadagathur M; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Guggilapu SD; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Uppu JL; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Tangellamudi ND; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Gangireddy PK; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India.
Godugu C; Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500037, India. Electronic address: chandra.niperhyd@gov.in.
Bathini NB; Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: bathini@iict.res.in.

Bioorg Chem ; 92: 103188, 2019 11.

Article en En | MEDLINE | ID: mdl-31450167

Asunto(s)

Antineoplásicos/síntesis química; Benceno/química; Indoles/síntesis química; Tiazolidinas/química; Moduladores de Tubulina/síntesis química; Tubulina (Proteína)/metabolismo; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Enlace de Hidrógeno; Interacciones Hidrofóbicas e Hidrofílicas; Indoles/farmacología; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Simulación del Acoplamiento Molecular; Estructura Molecular; Unión Proteica; Electricidad Estática; Relación Estructura-Actividad; Moduladores de Tubulina/farmacología

Palabras clave

Apoptosis; Benzyl/phenethyl thiazolidinone-indole hybrids; Cytotoxicity; Molecular modeling; Tubulin polymerization

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tubulina (Proteína) / Benceno / Moduladores de Tubulina / Tiazolidinas / Indoles / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: India

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google