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Perinatal carotid artery ischemic stroke: Report of two cases.
Suppiej, A; Toffoli, E; Festa, I; Cervesi, C; Cappellari, A; Manara, R; Magarotto, M; Cainelli, E.
Afiliación
  • Suppiej A; Department of Medical Sciences, Pediatric Section, University of Ferrara, Ferrara, Italy.
  • Toffoli E; Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy.
  • Festa I; Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy.
  • Cervesi C; Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy.
  • Cappellari A; Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy.
  • Manara R; Child Neurology and Clinical Neurophysiology, Pediatric University Hospital, Padua, Italy.
  • Magarotto M; Department of Neurosciences, Neuroradiology Unit, University of Salerno, Salerno, Italy.
  • Cainelli E; Neonatal Intensive Care Unit, Pediatric University Hospital, Padua, Italy.
J Neonatal Perinatal Med ; 12(4): 479-485, 2019.
Article en En | MEDLINE | ID: mdl-31450516
ABSTRACT
The mechanisms of perinatal stroke are poorly understood but preclinical studies point to the crucial role of perinatal inflammation. Carotid artery occlusion represents a very rare and severe cause of perinatal stroke. We describe two cases diagnosed with extensive ischemic stroke due to carotid artery occlusion. In both cases, we demonstrated placental vasculopathy. High levels of C-reactive protein in mother and/or neonates suggested inflammatory mechanism as a potential trigger. Both cases underwent hypothermic treatment without complications because of initial diagnosis of perinatal asphyxia. The prognosis at the time of the last follow up was severe including cerebral palsy, epilepsy and cognitive impairment. Our cases contribute to the actual debate on pathogenic mechanisms and treatment options for this rare condition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Carótidas / Infarto Cerebral / Isquemia Encefálica / Parálisis Cerebral / Trastornos del Neurodesarrollo / Enfermedades del Prematuro Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Newborn Idioma: En Revista: J Neonatal Perinatal Med Año: 2019 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Carótidas / Infarto Cerebral / Isquemia Encefálica / Parálisis Cerebral / Trastornos del Neurodesarrollo / Enfermedades del Prematuro Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child, preschool / Female / Humans / Newborn Idioma: En Revista: J Neonatal Perinatal Med Año: 2019 Tipo del documento: Article País de afiliación: Italia