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Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells.
Yang, Chen-Yu; Chen, Chi; Lin, Cheng-Yung; Chen, Yi-Hsuan; Lin, Chih-Yang; Chi, Chih-Wen; Chen, Yu-Jen; Liu, Shih-Chia; Chang, Ting-Kuo; Tang, Chih-Hsin; Lai, Yu-Wei; Tsai, Huai-Jen; Chen, Jih-Jung; Wang, Shih-Wei.
Afiliación
  • Yang CY; Department of Orthopaedics, MacKay Memorial Hospital, Taipei, Taiwan.
  • Chen C; Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, Taiwan.
  • Lin CY; Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
  • Chen YH; Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, Taiwan.
  • Lin CY; Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, Taiwan.
  • Chi CW; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan.
  • Chen YJ; Department of Medical Research, MacKay Memorial Hospital, New Taipei City, Taiwan; Department of Radiation Oncology, MacKay Memorial Hospital, Taipei, Taiwan.
  • Liu SC; Department of Orthopaedics, MacKay Memorial Hospital, Taipei, Taiwan.
  • Chang TK; Department of Orthopaedics, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, Taiwan.
  • Tang CH; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan.
  • Lai YW; Division of Urology, Taipei City Hospital Renai Branch, Taipei, Taiwan; Department of Urology, National Yang-Ming University School of Medicine, Taipei, Taiwan.
  • Tsai HJ; Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.
  • Chen JJ; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, No.155, Sec.2, Linong Street, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. Electronic address: chenjj@ym.edu.tw.
  • Wang SW; Department of Medicine, Mackay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, Taiwan; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: shihwei@mmc.edu.tw.
Phytomedicine ; 64: 152911, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31454653
ABSTRACT
Background Garcimultiflorone K is a novel polyprenylated polycyclic acylphloroglucinol isolated from the stems of Garcinia multiflora that exhibits promising anti-angiogenic activity in human endothelial progenitor cells (EPCs). Purpose This study sought to determine the underlying anti-angiogenic mechanisms and pharmacological properties of garcimultiflorone K. Methods We examined the anti-angiogenic effects of garcimultiflorone K and its mechanisms of action using in vitro EPC models and in vivo zebrafish embryos. Results EPCs proliferation, migration, differentiation and capillary-like tube formation were effectively and concentration-dependently inhibited by garcimultiflorone K without any signs of cytotoxicity. Our investigations revealed that garcimultiflorone K suppressed EPCs angiogenesis through Akt, mTOR, p70S6K, and eNOS signaling cascades. Notably, garcimultiflorone K dose-dependently impeded angiogenesis in zebrafish embryos. Conclusion Our data demonstrate the anti-angiogneic effects of garcimultiflorone K in both in vitro and in vivo models. Garcimultiflorone K appears to have potential in the treatment of angiogenesis-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Floroglucinol / Transducción de Señal / Inhibidores de la Angiogénesis / Garcinia / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Floroglucinol / Transducción de Señal / Inhibidores de la Angiogénesis / Garcinia / Neovascularización Patológica Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2019 Tipo del documento: Article País de afiliación: Taiwán