Association of Retinopathy and Insulin Resistance: NHANES 2005-2008.
Curr Eye Res
; 45(2): 173-176, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-31460803
ABSTRACT
Purpose:
In animal models, insulin resistance without severe hyperglycemia is associated with retinopathy; however, corroborating data in humans are lacking. This study aims to investigate the prevalence of retinopathy in a population without diabetes and evaluate the association of insulin resistance and retinopathy within this group.Methods:
The study population included 1914 adults age ≥40 without diabetes who were assigned to the morning, fasted group in the National Health and Nutrition Examination Survey 2005-2008, conducted by the Centers for Disease Control. Retinopathy was determined using fundus photos independently graded by a reading center and insulin resistance was determined using the homeostatic model of insulin resistance.Results:
Prevalence of retinopathy in those without diabetes was survey design adjusted 9.4% (174/1914). In multivariable analyses, retinopathy was associated with insulin resistance (HOMA-IR OR 1.09, 95% CI 1.03, 1.16; p = .0030), male gender (OR 1.39, 95% CI 1.04, 1.85; p = .0267), and age (OR 1.03, 95% CI 1.01, 1.05; p = .0203).Conclusions:
Insulin resistance in the absence of overt hyperglycemia could be an early driver of retinopathy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Retinopatía Diabética
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Curr Eye Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos