Viral and tumor antigen-specific CD8 T-cell responses in Merkel cell carcinoma.
Cell Immunol
; 344: 103961, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31472938
ABSTRACT
Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous cancer, which is immunogenic, regardless of the presence of MCPyV (80% of cases). The identification of MCC-specific epitopes recognized by CD8 T cells is crucial to expand the arsenal of immunotherapeutic treatments. Until now, most efforts focused on the identification of virus-specific epitopes, whereas immune responses directed against shared cellular tumor-specific antigens have not been evidenced. In this study, we measured T-cell responses against viral (nâ¯=â¯3) and tumor antigens (nâ¯=â¯47) from TILs derived from 21 MCC tumors. Virus-specific CD8 T-cell responses dominated MCC-specific immune responses, and we identified two new HLA-peptide complexes derived from the LT antigen, located in a region encompassing 3 previously identified epitopes. Finally, we show that MAGE-A3 antigen, frequently expressed by MCC tumors, was recognized by CD8 TILs from a virus-negative MCC tumor and thus could be a target for immunotherapy in this setting.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Carcinoma de Células de Merkel
/
Linfocitos T CD8-positivos
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cell Immunol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia