Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.

Walker, Caitlin; Wang, Yingjie; Olivieri, Cristina; Karamafrooz, Adak; Casby, Jordan; Bathon, Kerstin; Calebiro, Davide; Gao, Jiali; Bernlohr, David A; Taylor, Susan S; Veglia, Gianluigi

Walker, Caitlin; Wang, Yingjie; Olivieri, Cristina; Karamafrooz, Adak; Casby, Jordan; Bathon, Kerstin; Calebiro, Davide; Gao, Jiali; Bernlohr, David A; Taylor, Susan S; Veglia, Gianluigi.

Afiliación

Walker C; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Wang Y; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Olivieri C; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Karamafrooz A; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Casby J; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Bathon K; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Calebiro D; Institute for Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
Gao J; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.
Bernlohr DA; Centre of Membrane Proteins and Receptors, University of Birmingham, Birmingham B15 2TT, UK.
Taylor SS; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Veglia G; Shenzhen Bay Laboratory and Laboratory of Computational Chemistry and Drug Design, Peking University Graduate School, Shenzhen 518055, China.

Sci Adv ; 5(8): eaaw9298, 2019 08.

Article en En | MEDLINE | ID: mdl-31489371

Asunto(s)

Regulación Alostérica/genética; Síndrome de Cushing/genética; Proteínas Quinasas Dependientes de AMP Cíclico/genética; Mutación/genética; Adenoma Corticosuprarrenal/genética; Dominio Catalítico/genética; Subunidades Catalíticas de Proteína Quinasa Dependientes de AMP Cíclico/genética; Humanos; Hidrocortisona/genética; Especificidad por Sustrato

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Quinasas Dependientes de AMP Cíclico / Síndrome de Cushing / Regulación Alostérica / Mutación Límite: Humans Idioma: En Revista: Sci Adv Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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