Your browser doesn't support javascript.
loading
Nonsevere combined immunodeficiency T-cell lymphopenia identified through newborn screening.
Patrawala, Meera; Kobrynski, Lisa.
Afiliación
  • Patrawala M; Department of Pediatrics, Allergy/Immunology Section, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA.
Curr Opin Allergy Clin Immunol ; 19(6): 586-593, 2019 12.
Article en En | MEDLINE | ID: mdl-31490207
PURPOSE OF REVIEW: Although severe combined immunodeficiency (SCID) is the primary target condition for newborn screening (NBS), over 25 secondary targets, conditions other than SCID, have been identified. There is no standard method for evaluating neonates with non-SCID T-cell lymphopenia (TCL) and no standard approaches to treatment. We will describe these conditions and discuss recommendations for evaluating and follow-up of non-SCID TCL detected by NBS. RECENT FINDINGS: The birth prevalence of non-SCID TCL detected through SCID NBS is higher than SCID and can be a burden on NBS programs. We will present some publications discussing outcomes and comorbidities in these patients. SUMMARY: NBS for SCID has been very successful in identifying infants with SCID at birth to institute early life saving therapies. TCL due to other conditions can cause significant immune deficiency and treatment is dependent on the cause of the defect, as well as the magnitude of the immunodeficiency. Data collection from NBS programs should include assessment of various therapies and clinical outcomes. Better systems for recording long-term outcomes of SCID NBS including both SCID and non-SCID conditions should become a priority for NBS programs. This will help to advance the goal of NBS programs: improve outcomes in the most cost-effective manner.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Inmunodeficiencia Combinada Grave / Síndromes de Inmunodeficiencia Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans / Newborn Idioma: En Revista: Curr Opin Allergy Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Inmunodeficiencia Combinada Grave / Síndromes de Inmunodeficiencia Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans / Newborn Idioma: En Revista: Curr Opin Allergy Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos