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Functional Antagonism of Sphingosine-1-Phosphate Receptor 1 Prevents Harmaline-Induced Ultrastructural Alterations and Caspase-3 Mediated Apoptosis.
Dahmardeh, Narjes; Shabani, Mohammad; Basiri, Mohsen; Kalantaripour, Taj Pari; Asadi-Shekaari, Majid.
Afiliación
  • Dahmardeh N; Department of Anatomical Sciences, Afzalipour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran.
  • Shabani M; Department of Anatomical Sciences, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Basiri M; Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
  • Kalantaripour TP; Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
  • Asadi-Shekaari M; Department of Physiology, School of Medicine, Kerman Branch, Islamic Azad University, Kerman, Iran.
Malays J Med Sci ; 26(4): 28-38, 2019 Jul.
Article en En | MEDLINE | ID: mdl-31496891
BACKGROUND: There is a meaningful necessity for a targeted therapy of essential tremor (ET), as medications have not been developed specifically for ET. For nearly a century, many drugs have been applied in the treatment of tremor but the drug treatment of ET remains still unknown. Some potential therapeutic factors such fingolimod (FTY720) can be effectively used to treat ET in animals. In the present research, the effect of FTY720, the immunomodulatory sphingosine 1-phosphate (S1P) analog, on degeneration of cerebellar and olivary neurons induced by harmaline in male rats was investigated. METHODS: The animals were allotted into control dimethyl sulfoxide (DMSO), saline + harmaline [30 mg/kg, intraperitoneally, (i.p.)], harmaline + FTY720 (1 mg/kg, i.p, 1 h and 24 h before harmaline injection) groups (n = 10). The cerebellum and inferior olive nucleus (ION) were studied for neuronal degeneration using immunohistochemistry (IHC) and ultrastructural study by transmission electron microscopy (TEM) techniques. RESULTS: Harmaline caused neuronal cell loss, caspase-3 mediated apoptosis, astrocytosis and ultrastructural changes in cerebellar Purkinje cells and inferior olive neurons. FTY720 exhibited neuroprotective effects on cerebellar Purkinje cells and inferior olivary neurons. CONCLUSION: These results suggest that FTY720 has potential efficacy for prevention of ET neurodegeneration and astrocytosis induced by harmaline in male rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Malays J Med Sci Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Malasia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Malays J Med Sci Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Malasia