Your browser doesn't support javascript.
loading
Separation of Unprecedented Degradants of Domperidone by Ultra-Performance Convergence Chromatography and Their Structure Elucidation.
Mutha, V V S R N Anji Karun; Chandra, Chakravarthy; Vijayabhaskar, B; Achanta, Prabhakar S; Narkedimilli, Jagadeesh; Kaliyaperumal, Muralidharan; Korupolu, Raghu Babu; Gajbhiye, Susheela Bai; Rumalla, Chidananda Swamy.
Afiliación
  • Mutha VVSRNAK; Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd, IDA Mallapur, Hyderabad, Telangana 500076, India.
  • Chandra C; Department of Engineering Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.
  • Vijayabhaskar B; Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd, IDA Mallapur, Hyderabad, Telangana 500076, India.
  • Achanta PS; Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd, IDA Mallapur, Hyderabad, Telangana 500076, India.
  • Narkedimilli J; Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd, IDA Mallapur, Hyderabad, Telangana 500076, India.
  • Kaliyaperumal M; Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, Telangana 500085, India.
  • Korupolu RB; Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd, IDA Mallapur, Hyderabad, Telangana 500076, India.
  • Gajbhiye SB; Department of Engineering Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.
  • Rumalla CS; Department of Engineering Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh 530003, India.
J Chromatogr Sci ; 57(9): 806-814, 2019 Oct 17.
Article en En | MEDLINE | ID: mdl-31504287
Domperidone, a gastroprokinetic agent, is a common drug to treat emesis. It was subjected to acid, base-mediated hydrolysis, peroxide-mediated oxidation, photolysis and thermal degradation according to ICH guidelines to observe stability of the selected drug under the stress conditions. Although the drug is resistant to base hydrolysis, photolysis and thermal stressors, two degradants (DP-ISO1 and DP-ISO2) were formed in acid mediated hydrolysis. Oxidation with hydrogen peroxide also resulted in one product (DP-OX). All three degradants were isolated from the crude reaction mixture by preparative high-performance liquid chromatography and supercritical fluid chromatography. Structures of isolated compounds were unambiguously characterized as 5-chloro-1-(1-(3-(6-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (DP-ISO1), 5-chloro-1-(3-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (DP-ISO2), 4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)piperidine 1-oxide (DP-OX) by analysis of mass spectrometry, 1D and 2D nuclear magnetic resonance spectra. To the best of our knowledge, DP-ISO1 and DP-ISO2 are new and DP-OX was previously reported as domperidone impurity.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatografía Líquida de Alta Presión / Domperidona Idioma: En Revista: J Chromatogr Sci Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromatografía Líquida de Alta Presión / Domperidona Idioma: En Revista: J Chromatogr Sci Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos